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  Innovative Products Research & Services, Inc.
 
       a 501(3)(c) non profit organization based in Massachusetts with offices in NH and NC
               
   Putting Creativity to Good Use

GLOSSARY OF TERMS & ACRONYMS  IN CANCER RESEARCH

IPRS Web Site Version 

2D-DIGE

Two dimensional – differential gel electrophoresis

AA

Black or African American

AA

African American

ACN

Acetonitrile

ADT

Androgen deprivation therapy

ALT

Alanine transaminase

ANOVA

Analysis of Variance

AR

Androgen receptor

ASCs

Adipocyte stromal cells

AST

Aspartate aminotransferase

BER

Base excision repair

BLI

Bioluminescent imaging

CA

Caucasian

CAN

Copy number alteration

CART

Classification and regression tree

CK

Creatine kinase

CK5, -8  CK8

Cytokeratin-5

CNV

Copy number variant

cPten-/-L

Conditional probasin-luciferase expression

CTL

Cytotoxic T cell lymphocytes

DIGE

Differential gel electrophoresis

DMEM

Dulbecco's Modified Eagle Medium

DNA

Deoxyribonucleic acid

DTT

Dithiothritol

EA

Caucasian or European American

EGFR

Epidermal growth factor receptor

EPR

Enhance permeability and retention

ESI-QTOF

Electrospray ionization -quadrupole time-of-flight mass spectrometry

EZH2

Enhancer of zeste homolog 2

FACS

Fluorescence-activated cell sorter

FBS

Fetal bovine serum

FDA

Food and Drug Administration

FDR

False Discovery Rate

FFPE

Formalin-fixed, paraffin-embedded

FRá/FR1, - FRâ/FR2, - FRã/FR3, and -FRä/FR4

Folate receptors

gIFN

Interferon Gamma

GnRH

Gonadotropin-releasing hormone

GU

Georgetown University

HRP

Horseradish peroxidase

IFN

Interferon

IHC

Immunohistochemistry

IHC

Immunohistochemistry

II dichloride (cisplatin)

cis-diammineplatinum

IL

Interleukin

IL-4

Interleukin 4

IL-8

Interleukin 8

IL-10

Interleukin 10

IL-12

Interleukin 12

IL-13

Interleukin 13

IL-23

Interleukin 23

IRF1

Interferon Regulatory Factor-1

IHC

Immunohistochemistry

IF

Immunofluorescence

iNOS

Inducible nitric oxide synthase

IRB

International review board

iTRAQ

Isobaric tag for relative and absolute quantitation

IVIS

in vivo imaging system

KCNB2

Potassium voltage-gated channel subfamily B member 2

KCNMA1

Potassium large conductance calcium-activated channel, subfamily M, alpha

KCNQ3

Potassium voltage-gated channel, KQT-like subfamily, member 3

K-SFM

Keratinocyte serum free medium

LARS

Least angle regression

LC

Liquid chromatography

LC/MS

Liquid chromatography mass spectrometry

LC/MS/MS

Liquid chromatography tandem mass spectrometry

LCCC

Lombardi Comprehensive Cancer Center

m/z

Mass to charge ratio

MANOVA

Multivariate Analysis of Variance

MDA

Multivariate data analysis

MDOR

Minimum detectable odds ratios

MDS

Multi-dimensional scaling

MDSC

Myeloid derived suppressor cells

METS

Metastases

MMP7

Matix metalloprotein 7

MMP9

Matix metalloprotein 9

MMR

Mutations DNA mismatch repair

MRM

Multiple reaction monitoring

MS

Mass spectrometry

MS/MS

Tandem mass spectrometry

MYC

Avian myelocytomatosis viral oncogene homolog

NanoUPLC

Nanoflow ultra performance liquid chromatography

NanoUPLC-QTOFLCMS/MS

Nanoflow ultra performance liquid chromatography,

NER

Nucleotide excision repair

NIH

National Institute of Health, USA

NK

Natural killer cells

NFkB

Nuclear Factor Kappa B

NGS Next Generation Sequencing

NMR

Nuclear magnetic resonance

OPLS-DA

Orthogonal partial least square discriminant analysis.

OR

Odds ratio

PAR

Population attributable risk

PC

Prostate cancer

PCa

Prostate cancer

PCA

Principal components analysis

PCR 

Polymerase chain reaction (variations on prefix)

PDAC

Pancreatic ductal adenocarcinoma

PGA

Power for Genetic Association Analysis

PI

Principal investigator

PIN

prostatic intraepithelial neoplasia

PLS-DA

Projections to latent structures directed analysis

PMSR

Proteomics and Metabolomics Shared Resource

Power

Statistical measure of confidence

PPA

Proteomic Pathway Array

PSA

Prostate-specific antigen

PTEN tumor suppressor gene

Phosphatase and tensin homolog deleted on chromosome 10

QTOF/MS

Quadrupole- time of flight tandem mass spectrometry

RES

Reticuloendothelial system

RF

Random Forest (a statistical programming language)

RFC

Reduced folate carrier

ROC

Receiver operator curve

RPMI

Roswell Park Memorial Institute

SAM

Significant Analysis of Microarray

SCID

Severe Combined Immunodeficiency

SCX

Strong cation exchange chromatography

SD

Standard deviation

SEM

Standard Error of Means

SIMCA

Soft independent modeling of class analogy

SPINK1

Serine protease inhibitor kazal type 1 gene has recently been implicated in the biology of PCa. This study being conducted at National Human Genome

TAM

Tumor-associated macrophages

TGF

Transforming growth factor

TGFb

Tumor growth factor-Beta(1)

Th17 - type 17

T helper type 17

Th1

T helper cell, class 1.

Th2

T helper cell, class 2

TMA

Tissue microarray

TMN

Tumor, metastases, nodes

TNF

Tumor necrosis factor

TRAIL

TNF related apoptosis inducing factor

TRAMP

Transgenic adenocarcinoma mouse prostate

Treg

T regulatory

UPLC-TOFMS

Ultra performance Liquid Chromatography time-of-flight mass spectrometry (a form of LC-MS)

WA

White American

XPclad nanoparticles

Clad nanoparticles

 

 

PC or PDC

Partition distribution coefficient or partition coefficient is the ratio of concentrations of a compound in the two phases of a mixture of two immiscible solvents (e.g., water~hydrophilic and at equilibrium and octanol~hydrophobic) to predict the distribution of drugs (logP)

 

 

 

 

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Revised: February 13, 2024