The Magnesium Project
- Diseases Overview
Diseases and Conditions of Cation Regulation
The following list of diseases or conditions have at least one component
that may be attributed to an irregularity in cation metabolism and/or
regulation. To see at least one of the references making the connection
click on the disease or condition, continue in your review of the pages on this
site.
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Disease of the Brain - Alzheimers, Parkinsons's Disease, Schizophrenia/Depression and other neurological diseases
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Cancer - cell replication dysfunction, deficient energy
production (e.g. Prostate, Breast)
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Heart/CVS - Arrhythmias, Hypertension, Pre-eclampsia/Eclampsia
and other cardio-vascular systems (CVS) diseases including endothelial dysfunction
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Hypomagnesemia or Hypermagnesemia, other mineral disorders
(Osteoporosis)
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Immune System - Auto-immune diseases (Multiple Sclerosis),
Rheumatoid arthritis, Juvenile (Type I) Diabetes.
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Metabolic Diseases - Diabetes -
Type II
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Muscle diseases - Dystonias, Muscular Dystrophy, Pain and Spasms
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Neurology - Nerve/muscle interface dysfunction, transmitters,
other control disorders
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Nutrition - mineral deficiencies from water and/or food intake
Specific indicators to be alert for when dealing with these diseases are
the blood electrolyte levels. If the Magnesium level is higher or lower
than normal, that condition would be designated as either Hypermagnesemia or
Hypomagnesemia respectively. It may also be important to look for abnormal
levels of Ca, Na, and K. Often the physiological effects are not only
level sensitive but also ratio sensitive. Thus a low Mg may not be as
much of a problem for some diseases if the Ca were also low. Similarly,
Mg/K and Ca/K and Na/K ratios are often good indicators of impending
malfunction as much as the absolute levels, though the later are certainly
important.
Mineral Utilization and Regulation
Diseases/conditions that contribute to lower or higher electrolyte levels in
the blood and/or tissue are the following:
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Hyper Phosphatemia - phosphate is often chemically associated with
divalent cations like Ca and Mg. Thus changes in phosphate levels will
potentially alter at least the free activity level of the Ca and Mg ions in the
blood.
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pH changes as through the oxygen/carbon dioxide balance will also impact
the extent to which Ca and Mg in particular are bound to blood proteins or are
free to move across cell boundaries.
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Hyper or Hypo Parathyroidism - changes in levels of PTH (parathyroid
hormone).
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Carcinoma of Thyroid/Parathyroid gland - may lead to an excess in PTH.
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Surgical removal of Thyroid/Parathyroids - may lead to a drop in PTH.
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Chemical or radiation treatment directed at thyroid/parathyroid tissues -
may lower PTH.
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Analogous conditions of the adrenal (suprarenal) glands that would impact
mineralocorticoids (aldosterone et al.) synthesis and Na+/K+ regulation and
ACTH (adrenal corticotrophic hormone).
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Analogous conditions of the anterior pituitary gland that may alter
hormones levels such as ACTH, PTH and Thyroid Stimulating Hormone (TSH),
et al.
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Analogous conditions of the posterior pituitary gland that may alter
levels of antidiuretic hormone (ADH) which in turn influences the salt
concentration in the blood.
Genetic conditions that may be pre-disposing to any of the foregoing
conditions are yet to be evaluated. For further treatment of genetics see the
Genomics pages.
Other Diseases
There are
Other Diseases that may be influenced by electrolyte metabolism and regulation.
References:
An extensive bibliography has been compiled with the aid of numerous
volunteers.
© 2013-2014, All Rights Reserved, IPRS Inc.
Revised:
March 19, 2014
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