Basic Research on Muscles, Nerves and Electrolytes by Dr. Job

We have been engaged in basic research on the role and interactions of electrolytes in muscles and nerves for more than 40 years. The work has included work on smooth muscle as well as skeletal muscle. The species studied ranged from sponges and plants to mammals including humans. We have also engaged in research on innervation of muscle and the experiencing of pain emanating from skeletal muscle. Research tools have included radioisotope labeling, biochemical analysis, electrophysiology and computer-based signal processing. Outputs have included biophysical models as well as a number of discoveries and published findings. See more details and links below.

 Job, D. D.  "Ionic basis of intestinal electrical activity."  Am. J. Physiol. 217: 1533-1541, 1969
       View a copy of cover page     AJP 217: 1533, 1969

 Job, D. D.  "Effects of antibiotics and selective inhibitors of ATP on intestinal slow waves."  Am. J. Physiol. 220 (2): 299-306, 1971.
        View a copy of cover page     AJP 220: 299, 1971

 Job, D. D. and W. Griffing and B. Rodda.  "A possible origin of intestinal gradients and their relation to motility."  Am. J. Physiol.  226 (6): 1510-1515, 1974.
        View a copy of cover page     AJP 226: 1510, 1974

 Job, D. D., W. E. Bloomquist and J. Bridgeforth.  "Correlations between electrolyte content and spontaneous electrical activity in intestinal muscle."  Am. J. Physiol.  226(6): 1502-1509, 1974.
        View the article     AJP 226: 1502, 1974

 Job, D. D. and W.E. Bloomquist.  "Correlations between ionic contents in different regions and layers of intestinal muscle."  Am. J. Physiol.  226(6): 1496-1501, 1974.
        View a copy of cover page     AJP 226: 1496, 1974

 Lui, J., C. L. Prosser and D. D. Job  "Ionic dependence of slow waves and spikes in intestinal muscle."  Am. J. Physiol.  217: 1542-1550, 1969.
        View the article    AJP 217: 1542-1550, 1969

 Job, D. D. and B. J. Cerimele and S. R. Lawrence.  "Computer analysis of intestinal motility"  Fed. Proc. 33(3): 391, Paper #1020, 1974.
        View image of abstract    FASEB-1974, Fourier Analysis Abstract

 Job, D. D. and B. Cerimele.  "Fourier analysis of electrical activity from different regions of the gastro-intestinal tract: Biophysics Journal 13: 199a, 1973.

 ____________ and K. Martlage.  "Calcium ion complexes with phospholipids."  Biophysical Journal 11: 57a, 1971.

 ____________ "The effects of metabolic inhibitors on phosphate efflux from smooth muscle." Fed. Proc. 29(2): 806, 1970.

 ____________ "ATP hydrolysis during slow wave repolarization".  Biophysical Journal 10: 117, 1970

 ____________  "Origin and Mechanism of Intestinal Slow Waves."  Ph.D. Dissertation, Dept. of Physiology and Biophysics, University of Illinois, Urbana, IL 1968.  Published in Dissertation Abstracts XXX(1),  1969.

 ____________ "Origin of slow wave frequency". Fed. Proc. 28(2): 541, 1969.

 ____________ and B. C. Abbott.  "Ionic basis for intestinal slow waves."  Fed. Proc. 27: 704, 1968.

 Boling, J. L. and D. D. Job "Studies of the influence of estrogens and progesterone effects on abdomino-vaginal electro-potential differences and muscular activity of the vagina in the albino rat."  Anatomical Record, 151: 326-327, 1965.

 "Calcium ion complexes with phospholipids".  Seminar given to the Transport Group at Indiana University Medical School, March, 1973.

NASSHP – “A Systems Biology View of Magnesium and Hypertension in Pregnancy.”  Presented at Biennial  meeting of the North American Society for the Study of Hypertension in Pregnancy.  Kiawah Island Resort, SC, Sept. 7-9, 2012.

Recent Research on Plants by Dr. Job

The study of plants offers interesting parallels to the study of animals. Many of the systems are similar if not identical with respect to the biochemistry, regulatory mechanisms and genomics.  Thus for example the plant Arabidopsis thaliana has a very well characterized and annotated genome yet it is smaller (fewer base pairs) than the human genome and more tractable to modification and analysis.  Other plants are also well characterized with respect to genes and proteins.  Plant hormones may have parallels as well.  For example auxin (indole-3-acetic acid or IAA) regulates growth in plants which may be similar in function to growth hormones in the mammal.  Conducting research on plants is also easier and more economical than doing animal studies. 

For these reasons among others, we have initiated some research on different plant species in part as a preliminary discovery platform that could be carried over into mammalian and human application.  The following papers report our recent findings on the sub-tropical plant reputedly offering many health benefits, the Moringa oleifera.

Job,  D. D. "Moringa as a Source of Minerals?  A Comparison with Corn and Soybean."  First Published to this website, 2018.  ca. 19 pages.
        View the article    Moringa..., 2018a

Job,  D. D. "Feasibility of Growing Moringa in a Temperate Climate:  Lessons and Insights I., 2018b.  First Published to this website, 2018.  ca. 23 pages.
        View the article   Moringa..., 2018b

Job,  D. D. "Mineral Analysis of Moringa oleifera:  Electrolyte Interactions." 2018c.  First Published to this website, 2018. ca. 31 pages.
        View the article   Moringa..., 2018c

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